|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The upregulation of TMPO-AS1, TMPO mRNA and protein levels were associated with tumor progression of NSCLC.
|
31230752 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, studies conducted in GC cells indicated that knockdown of TMPO-α suppressed cell proliferation and invasion.
|
31602262 |
2019 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells.
|
31602262 |
2019 |
|
Sensorineural Hearing Loss (disorder)
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
From transcriptome to proteome: differentially expressed proteins identified in synovial tissue of patients suffering from rheumatoid arthritis and osteoarthritis by an initial screen with a panel of 791 antibodies.
|
12833524 |
2003 |
|
prostatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.
|
31271729 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Regulation of protein kinase C-related kinase (PRK) signalling by the TPα and TPβ isoforms of the human thromboxane A<sub>2</sub> receptor: Implications for thromboxane- and androgen- dependent neoplastic and epigenetic responses in prostate cancer.
|
28108419 |
2017 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Comparative genomic CpG DNA methylation analysis revealed substantial differences in the extent of methylation of the promoter regions of the TBXA2R that specifically regulate expression of TPα and TPβ, respectively, both in benign prostate and in clinically-derived tissue representative of precursor lesions and progressive stages of PCa.
|
27689401 |
2016 |
|
Progression of non-small cell lung cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Long noncoding RNA TMPO-AS1 promotes progression of non-small cell lung cancer through regulating its natural antisense transcript TMPO.
|
31230752 |
2019 |
|
Primary malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study suggests that TPα and TxAS are the ideal targets against smoking-related lung cancer.
|
24115277 |
2013 |
|
Primary malignant neoplasm of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Thymopoietin (TMPO) has been demonstrated to be upregulated in various tumors, including lung cancer, breast cancer, and so on, but its role in GBM has not been reported.
|
27756319 |
2016 |
|
Primary malignant neoplasm of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The transcription of TMPO gene in human lung cancer was analyzed using Oncomine platform (www.oncomine.org) according to the standardized procedures described previously.
|
31190881 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
From the above results, we conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2β regulates motility of cancer cells and suggest that LAP2β may have utility for diagnostics and therapeutics in digestive tract cancers.
|
22745766 |
2012 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of thymopoietin by miR-139-5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma.
|
31516562 |
2019 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Enhanced expression of <i>ESR1</i> mRNA by <i>TMPO-AS1</i> could play a critical role in the proliferation of ER-positive breast cancer.
|
31501276 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The upregulation of TMPO-AS1, TMPO mRNA and protein levels were associated with tumor progression of NSCLC.
|
31230752 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer.
|
31190881 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.
|
28902428 |
2018 |
|
Neutrophil abnormality
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
These results indicate that expression of NGF or NT-3 driven by LAP2 is sufficient to prevent the development of neuropathy 6 months after vector inoculation in rats.
|
15927533 |
2005 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Expression levels of both C/EBPalpha isoforms, C/EBPbeta isoforms LAP1, LAP2 (liver-enriched transcriptional activating proteins), and LIP (liver-enriched transcriptional inhibitory protein), and C/EBPdelta in the tumors were correlated with clinicopathological tumor parameters, expression of estrogen and progesterone receptors (ER, PR), Ki67 immunostaining, and expression of seven cell-cycle regulatory proteins which had been analyzed before.
|
12825852 |
2003 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Expression of TPα correlated with increasing prostate and breast tissue tumor grade while the TXA(2) mimetic U46619 promoted both proliferation and migration of the respective prostate (PC3) and breast (MCF-7 and MDA-MD-231) derived-carcinoma cell lines.
|
24747176 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The in vitro studies showed that TPα rather than TPβ promoted tumor growth, and NNK increased TPα.
|
24115277 |
2013 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
While TPα was more variably expressed than TPβ in PCa, increased/high TPα expression within the tumour also trended toward increased BCR and shorter disease-free survival time.
|
27689401 |
2016 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the overexpression of TMPO-α in gastric tissues (56%) was positively associated with Lauren classification (<i>P</i> = 0.0159), nodal status (<i>P</i> = 0.0265), distant metastasis (<i>P</i> < 0.0001), stage (<i>P</i> = 0.0367), and degree of differentiation (<i>P</i> = 0.0009).
|
31602262 |
2019 |